Bruger:Metalindustrien/KasseTech

Metalindustrien/KasseTech
Identifikatorer
	IUPAC-navn (2R,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)oxolane-2-carbonitrile;
CAS-nummer	1191237-69-0;
PubChem CID	44468216;
Kemiske og fysiske data
3D-model (JSmol)	Interaktivt billede;
	SMILES C1=C2C(=NC=NN2C(=C1)[C@]3([C@@H]([C@@H]([C@H](O3)CO)O)O)C#N)N;
	InChI InChI=1S/C12H13N5O4/c13-4-12(10(20)9(19)7(3-18)21-12)8-2-1-6-11(14)15-5-16-17(6)8/h1-2,5,7,9-10,18-20H,3H2,(H2,14,15,16)/t7-,9-,10-,12+/m1/s1; Key:BRDWIEOJOWJCLU-LTGWCKQJSA-N;

GS-441524 er et antiviralt stof, der blev udviklet af Gilead Sciences. It is the main plasma metabolite of the antiviral prodrug remdesivir, which has a half-life of around 24 hours in human patients. Remdesivir and GS-441524 were both tested against feline infectious peritonitis (FIP) in cell culture and found to be equivalent. Remdesivir was never tested in cats but GS-441524 has been found to be effective treatment for FIP, a lethal coronavirus disease which affects domestic cats and is widely used despite no official FDA approval due to Gilead's refusal to license this drug for veterinary use.^[1]^[2]^[3]^[4]

^ Westgate, James (7 maj 2020). "Vet science 'being ignored' in quest for COVID-19 drug". vet times. Hentet 6 juli 2020.{{cite news}}: CS1-vedligeholdelse: Dato automatisk oversat (link)
^ Zhang, Sarah (8 maj 2020). "A Much-Hyped COVID-19 Drug Is Almost Identical to a Black-Market Cat Cure". The Atlantic. Hentet 6 juli 2020.{{cite news}}: CS1-vedligeholdelse: Dato automatisk oversat (link)
^ Murphy BG, Perron M, Murakami E, Bauer K, Park Y, Eckstrand C, Liepnieks M, Pedersen NC (juni 2018). "The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies". Veterinary Microbiology. 219: 226-233. doi:10.1016/j.vetmic.2018.04.026. PMC 7117434. PMID 29778200.{{cite journal}}: CS1-vedligeholdelse: Dato automatisk oversat (link)
^ Pedersen NC, Perron M, Bannasch M, Montgomery E, Murakami E, Liepnieks M, Liu H (april 2019). "Efficacy and safety of the nucleoside analog GS-441524 for treatment of cats with naturally occurring feline infectious peritonitis". Journal of Feline Medicine and Surgery. 21 (4): 271-281. doi:10.1177/1098612X19825701. PMC 6435921. PMID 30755068.{{cite journal}}: CS1-vedligeholdelse: Dato automatisk oversat (link)

[vettimes-1] Westgate, James (7 maj 2020). "Vet science 'being ignored' in quest for COVID-19 drug". vet times. Hentet 6 juli 2020.{{cite news}}: CS1-vedligeholdelse: Dato automatisk oversat (link)

[atlantic-2] Zhang, Sarah (8 maj 2020). "A Much-Hyped COVID-19 Drug Is Almost Identical to a Black-Market Cat Cure". The Atlantic. Hentet 6 juli 2020.{{cite news}}: CS1-vedligeholdelse: Dato automatisk oversat (link)

[3] Murphy BG, Perron M, Murakami E, Bauer K, Park Y, Eckstrand C, Liepnieks M, Pedersen NC (juni 2018). "The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies". Veterinary Microbiology. 219: 226-233. doi:10.1016/j.vetmic.2018.04.026. PMC 7117434. PMID 29778200.{{cite journal}}: CS1-vedligeholdelse: Dato automatisk oversat (link)

[4] Pedersen NC, Perron M, Bannasch M, Montgomery E, Murakami E, Liepnieks M, Liu H (april 2019). "Efficacy and safety of the nucleoside analog GS-441524 for treatment of cats with naturally occurring feline infectious peritonitis". Journal of Feline Medicine and Surgery. 21 (4): 271-281. doi:10.1177/1098612X19825701. PMC 6435921. PMID 30755068.{{cite journal}}: CS1-vedligeholdelse: Dato automatisk oversat (link)

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